hrp0094fc9.1 | Growth Hormone and IGFs | ESPE2021

How to interpret growth hormone stimulation test results in children and adolescents with overweight and obesity? A systematic review and meta-analysis and evidence-based proposal for weight-status adjusted cut-offs

Abawi Ozair , Augustijn Dieuwertje , Hoeks Sanne , Rijke Yolanda de , van den Akker Erica ,

Background: Peak stimulated growth hormone (GH) levels are known to decrease with increasing BMI, possibly leading to overdiagnosis of GH deficiency (GHD) in children with overweight and obesity. However, current guidelines do not provide guidance how to interpret peak GH values of these children. The aim of this systematic review and meta-analysis was to study the effect of BMI standard deviation score (SDS) on stimulated peak GH values in children, to identi...